Multi‐Material 3D Microprinting of Magnetically Deformable Biocompatible Structures

Two-photon polymerization (2PP) allows precise 3D printing at the micrometer scale, and by associating it with magnetic materials, creation of remotely actuatable micro-structures. Such structures attract a growing interest for biomedical applications, thanks to their size biocompatibility some photoresist materials. Gelatin methacryloyl (Gel-MA) is one such material, can be used create physiological scaffolds cell culture. Here, physico-chemical properties two resins are exploited, first being silica-based hybrid polymer, OrmoComp, second Gel-MA-based hydrogel. A 2PP manufacturing protocol defined designed print both materials in succession as single structure, which then linked neodymium-iron-boron (NdFeB) bead actuation. By this combination, magnetically deformable culture substrate created study cells an environment that mimics soft, curved, dynamic tissues vivo. The structure actuated via external field bends back forth along its longest axis. Lastly, preliminary trials conducted showing proliferation on structures.